50% efficacy dose of intravenous lidocaine in supressing sufentanil-induced cough in children: a randomised controlled trial.

BACKGROUND: Opioids such as sufentanil are used as anaesthetics due to their rapid action and superior analgesic effect. However, sufentanil induces a huge cough in paediatric patients. In contrast, intravenous (IV) lidocaine suppresses opioid-induced cough in children, but its use is limited due to anaesthetists' concern about its toxicity. Therefore, this study aimed to evaluate the effect of dose-dependent IV lidocaine on sufentanil-induced cough (SIC) in paediatric patients. METHODS: A total of 188 patients aged 3-12 years scheduled for elective tonsillectomy with or without adenoidectomy were enrolled and divided into four groups depending on different dose of lidocaine: A (0 mg.kg-1), B (1 mg.kg-1), C (1.5 mg.kg-1), and D (2 mg.kg-1). The primary outcome was the SIC grade observed during the induction of general anaesthesia. The secondary outcomes were the incidence of SIC, mean arterial pressure, and heart rate at T0, T1, T2, T3, T4, and T5. RESULTS: The SIC grade was significantly different between groups A and D (P = 0.04) and between groups B and D (P = 0.03). Moreover, the incidence of SIC in groups A, B, C, and D was 81%, 87%, 68%, and 64%, respectively, and the difference between groups B and C (P = 0.03) and between groups B and D (P = 0.0083) was statistically significant. No statistical differences were observed in the hemodynamic parameters between the groups. The incidence of severe cough was statistically different between group D and group A (P < 0.0001), between group D and group B (P < 0.0001), and between group D and group C (P < 0.0001) respectively. CONCLUSIONS: Lidocaine suppresses SIC in a dose-dependent manner without severe adverse events. IV lidocaine can be used in paediatric patients safely and efficiently, and the median effective dose was 1.75 mg/kg. TRIAL REGISTRATION: This study was approved by the Institutional Review Board of Yichang Central People's Hospital (HEC-KYJJ-2020-038-02), The trial was registered at www.chictr.org.cn (ChiCTR2100053006).

Nano La(OH)3 modified lotus seedpod biochar: A novel solution for effective phosphorus removal from wastewater.

Effective removal of phosphorus from water is crucial for controlling eutrophication. Meanwhile, the post-disposal of wetland plants is also an urgent problem that needs to be solved. In this study, seedpods of the common wetland plant lotus were used as a new raw material to prepare biochar, which were further modified by loading nano La(OH)3 particles (LBC-La). The adsorption performance of the modified biochar for phosphate was evaluated through batch adsorption and column adsorption experiments. Adsorption performance of lotus seedpod biochar was significantly improved by La(OH)3 modification, with adsorption equilibrium time shortened from 24 to 4 h and a theoretical maximum adsorption capacity increased from 19.43 to 52.23 mg/g. Moreover, LBC-La maintained a removal rate above 99% for phosphate solutions with concentrations below 20 mg/L. The LBC-La exhibited strong anti-interference ability in pH (3-9) and coexisting ion experiments, with the removal ratio remaining above 99%. The characterization analysis indicated that the main mechanism is the formation of monodentate or bidentate lanthanum phosphate complexes through inner sphere complexation. Electrostatic adsorption and ligand exchange are also the mechanisms of LBC-La adsorption of phosphate. In the dynamic adsorption experiment of simulated wastewater treatment plant effluent, the breakthrough point of the adsorption column was 1620 min, reaching exhaustion point at 6480 min, with a theoretical phosphorus saturation adsorption capacity of 6050 mg/kg. The process was well described by the Thomas and Yoon-Nelson models, which indicated that this is a surface adsorption process, without the internal participation of the adsorbent.

Response of bacterial community composition and co-occurrence network to straw and straw biochar incorporation.

Microbial decomposition plays a crucial role in the incorporation of straw and straw biochar (SSB) into soil. Lime concretion black soil (LCBS) is a typical low-medium crop yield soil, and it is also one of the main soil types for grain production in China. However, the link between SSB additions and soil bacterial communities in LCBS remains unclear. This study explored the effects of SSB incorporation on bacterial community composition, structure and co-occurrence network patterns at different soil depths and maize growth stages. The results showed that soil PH, soil organic matter and total nitrogen significantly affected the seasonality and stratification of the soil bacterial community. The composition and diversity of bacterial communities were significantly affected by growth period and treatment rather than soil depth. Specifically, the bacterial community diversity increased significantly with crop growth at 0-20 cm, decreased the relative abundance of Actinobacteria, and increased the relative abundance of Proteobacteria and Acidobacteria. SF (straw with fertilizer) and BF (straw biochar with fertilizer) treatments decreased bacterial community diversity. Co-occurrence networks are more complex in BF, S (straw), and SF treatments, and the number of edge network patterns is increased by 92.5, 40, and 60% at the maturity stage compared with F (fertilizer) treatment, respectively. Moreover, the positive effect of straw biochar on the bacterial network pattern increased with time, while the effect of straw weakened. Notably, we found that rare species inside keystone taxa (Gemmatimonadetes and Nitrospirae) play an indispensable role in maintaining bacterial network construction in LCBS. This study offers a comprehensive understanding of the response of soil bacterial communities to SSB addition in LCBS areas, and provides a reference for further improvement of LCBS productivity.

Estimation of variability in soil water content in a forested critical-zone experimental catchment in Eastern China.

Knowledge of soil water content (SWC) dynamics within soil profiles is crucial for the effective management of water and soil resources. This study aims to clarify the temporal variability and stability of SWC in a forested critical-zone experimental catchment, and further to improve the understanding of the temporal and spatial distribution of soil water in a typical hilly catchment in eastern China. The selected Nandadish (NDD) catchment covering 0.79 ha was instrumented with 34 SWC monitoring sites using Frequency Domain Reflectometry. The consecutive high-resolution monitoring data of soil water at different depths of the sites were collected from January 2017 to December 2019. The results showed that the SWC of the shallow layer (0-30 cm) had the strongest variability over time during the three hydrologic years. The interannual variability of SWC showed the opposite regularity with that of the seasonal variability. Specifically, the spatial variability of SWC in the dry years was greater than that in wet years; whilst the temporal stability of SWC in dry seasons was greater than that in rainy seasons. Precipitation and temperature were the two dominant factors influencing the temporal variation of SWC. Precipitation controlled the interannual variation of SWC, while temperature controlled the seasonal variation of SWC. Additionally, soil water had high temporal stability throughout the observation period in NDD catchment, and the most representative point was located at a relatively flat and central place, which can be used to simulate the variability of SWC under different rainfall conditions in the study area. The temporal stability of SWC patterns was controlled by topography, geographic location, throughfall, and the groundwater level in the study area, which was characterized by sloping terrain and forested cover. This research provides scientific bases for the optimum design of ground sampling, and the temporal and spatial prediction for soil moisture in a typical eastern hilly area with forest land uses.

Evaluating the contribution of different environmental drivers to changes in evapotranspiration and soil moisture, a case study of the Wudaogou Experimental Station.

Evapotranspiration and soil moisture content (SMC) are key elements of the hydrological cycle. Accurate prediction of the dynamic processes of evapotranspiration and soil water is essential for irrigation and water management. Here, the boosted regression tree (BRT) method was employed to quantify environmental controls on actual evapotranspiration (ETa), potential evapotranspiration (ET0), and SMC using monitoring data from the Wudaogou hydrological experimental station. The results indicated that: (1) the BRT algorithm was effective in predicting the relative control of different environmental factors on ETa, ET0, and SMC; and (2) vapor pressure deficit (VPD) was the most important factor affecting daily ET0, and sunshine duration (SSD) also played a nonnegligible role. The results further explained the phenomenon of the "evaporation paradox" in the study area. SSD could be a leading control on daily ETa, followed by VPD, leaf area index (LAI). (3) Among the underground factors, groundwater level (GL) and LAI played a dominant role in the relative contribution to SMC. Among the aboveground factors, relative humidity (RH) and soil temperature (TS) have a relatively large influence on SMC. (4) The differences in SMC at different depths were determined by multiple influencing factors, including LAI, VPD, and precipitation (P). This study also underscores the importance of vegetation variations to hydrological cycle processes. In general, climate warming and an increase in extreme rainfall events will increase the control of temperature on SMC and weaken the control of P on SMC in the future.

Clinical Assessment of Histidine-Tryptophan-Ketoglutarate Solution and Modified St. Thomas' Solution in Pediatric Cardiac Surgery of Tetralogy of Fallot.

The objective of this study is to compare the myocardium protective effect of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) solution versus Modified St. Thomas' (STH) solution in pediatric cardiac surgery of Tetralogy of Fallot (TOF). Seventy-seven pediatric patients of TOF who received the total surgical repair were reviewed, from January 2014 to October 2015. A horizontal comparison between HTK solution and modified STH solution has been made since the HTK solutions were started to be used in our hospital. The patients were divided into the HTK group (n = 35) and the STH group (n = 33). The perioperative values of the groups were assessed in this study. The primary endpoints including spontaneous cardiac re-beating time, intensive care unit (ICU) stay, overall stay, mechanical ventilation postoperation, postoperation stay, overall stay, and perioperative echocardiographic results were analyzed in this study. We found that spontaneous cardiac re-beating time of the HTK group was significantly shorter than that of the STH group (0.26 min ± 0.56 vs. 1.33 ± 1.02, P < 0.001). There were no significant differences between the two groups in ICU stay (P = 0.29), postoperative mechanical ventilation time (P = 0.84), overall stay (0.73); and the mortalities of the two groups were similar (2.9 vs. 3.0%). Aimed at pediatric cardiac surgery of TOF, this study suggests that with similar aorta cross-clamping time, modified STH solution is as safe as HTK solution.